CONCURRENT SESSION III LIVER - FRONTIERS IN HEPATOLOGY

CFLD: FINDING THOSE AT RISK
Simon Ling MD, Hospital for Sick Kids
Learning objectives:
At the end of this presentation, attendees will be able to:
1. Understand the continuing importance of CF liver disease in the era of CFTR modifier therapies
2. Interpret clinical biomarkers of CFLD in line with recent research, including laboratory- and imaging-based tests
3. Appreciate future directions of CFLD biomarker research
Simon Ling MD - Slides
(Adobe PDF File)
ENGINEERING HUMAN LIVER ORGANOIDS FOR MODELING OF INHERITED CHOLESTASIS
Akihiro Asai MD, PhD, Cincinnati Children's Medical Center, Cincinnati, OH
Akihiro Asal MD - Slides
(Adobe PDF File)
RESULTS OF THE WUPPSC STUDY: PROSPECTIVE MULTICENTER WITHDRAWAL OFURSODEOXYCHOLIC
ACID IN PEDIATRIC PRIMARY SCLEROSING CHOLANGITIS (PSC). Dennis Black1, Cara Mack2, Nanda Kerkar3,5, Tamir Miloh4, Shikha Sundaram2, Ravinder Anand6, Ashutosh Gupta6, Estella Alonso7, Ronen Arnon8, Pinar Bulut9, Saul Karpen10, Chuan-Hao Lin5, Philip Rosenthal11, Matthew Ryan12, Robert Squires13, Pamela Valentino14, Benjamin Shneider4. 1Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA; 2Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA; 3Pediatrics, University of Rochester Medical Center, Rochester, NY, USA; 4Pediatrics, Baylor College of Medicine, Houston, TX, USA; 5Pediatrics, Keck School of Medicine of USC, Los Angeles, CA, USA; 6Emmes Corporation, Rockville, MD, USA; 7Pediatrics, Northwestern University College of Medicine, Chicago, IL, USA; 8Pediatrics, Mount Sinai Icahn School of Medicine, New York, NY, USA; 9Pediatrics, Phoenix Children's Hospital, Phoenix, AZ, USA; 10Pediatrics, Emory University School of Medicine, Atlanta, GA, USA; 11Pediatrics, University of California, San Francisco, School of Medicine, San Francisco, CA, USA; 12Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; 13Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; 14Pediatrics, Yale School of Medicine, New Haven, CT, USA.
 
Dennis Black MD - Slides
(Adobe PDF File)
DRUG INDUCED LIVER INJURY
Jean Molleston MD, Riley Children’s Hospital
Learning objectives:
1. Identify patterns of drug-induced liver injury in children
2. Know the drugs most commonly associated with pediatric DILI
3. Recognize phenotypes of DILI associated with specific drugs
Jean Molleston MD - Slides
(Adobe PDF File)
LIPOTOXICITY AND HEPATIC INFLAMMATION
Samar Ibrahim, MBChB – Mayo Clinic, Rochester, MN
Samar Ibrahim MBChB - Slides
(Adobe PDF File)