CONCURRENT SESSION IV - INFLAMMATORY BOWEL DISEASE: STATE OF THE ART RESEARCH

LESSONS LEARNED FROM RISK AND PROTECT: HOW THESE STUDIES IMPACT IBD CARE TODAY
Joel Rosh MD, Goryeb Children’s Hospital
Learning objectives:
1. Review recent data regarding therapeutic outcomes in pediatric IBD
2. Discuss the emerging data on the biology of IBD including genetic and microbiome findings
3. Identify biomarkers and clinical predictors of IBD disease progression
Joel Rosh MD - Slides
(Adobe PDF File)
THE IMPACT OF THE UNFOLDED PROTEIN RESPONSE ON REGULATORY CELLS
Edwin de Zoeten MD, PhD, Children's Hospital Colorado, Aurora, CO
LOSS-OF-FUNCTION CARD8 MUTATION CAUSES NLRP3 INFLAMMASOME ACTIVATION AND CROHN'S
DISEASE. Liming Mao1, Atsushi Kitani1, Morgan Similuk2, Andrew Oler3, Lindsey Albenberg4, Judith Kelsen4, Atiye Aktay5, Martha Quezado6, Michael Yao7,1, Kim Montgomery-Recht8,1, Warren Strober1, Ivan Fuss1. 1Mucosal Immunity Section, National Institutes of Health, Bethesda, MD, USA; 2Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA; 3Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institutes of Health, Bethesda, MD, USA; 4Division of Pediatric Gastroenterology, Children’s Hospital of Philadelphia, Philadelphia, MD, USA; 5Division of Pediatric Gastroenterology, UH Cleveland Medical Center , Cleveland, OH, USA; 6Laboratory of Pathology, NCI, National Institutes of Health, Bethesda, MD, USA
Ivan Fuss MD - Slides
(Adobe PDF File)
BIOMARKERS AND PREDICTING DISEASE
Anne Griffiths MD, Hospital for Sick Children
Learning objectives:
1. Understand the limitations of current biomarkers in predicting clinical course of IBD
2. Be able to critically utilize fecal inflammatory biomarkers in monitoring treatment response in IBD
3. Appreciate the need for development of novel biomarkers to predict responsiveness to biologictreatments
Anne Griffiths MD - Slides
(Adobe PDF File)
INFLIXIMAB MONOTHERAPY VS. COMBINATION THERAPY WITH IMMUNOMODULATORS FOR MAINTENANCE TREATMENT OF PEDIATRIC INFLAMMATORY BOWEL DISEASE: AN EVOLVING ROLE FOR
METHOTREXATE POLYGLUTAMATES MONITORING. Valentina Shakhnovich1,2, Rebecca Casini1, Ryan Morrow3,
Kyle Gress4, Leon Van Haandel3, Mara Becker3, Ryan Funk5. 1Gastroenterology, Children's Mercy Kansas City, Kansas City, MO, USA; 2Clinical Pharmacology, Children's Mercy Kansas City, Kansas City, MO, USA; 3Children's Mercy Kansas City, Kansas City, MO, USA; 4Georgetown University School of Medicine, Washington DC, , USA; 5University of Kansas Medical Center, Kansas City, KS, USA.