CONCURRENT SESSION V - NEUROGASTROENTEROLOGY AND MOTILITY: INTERVENTIONAL ADVANCES IN MOTILITY

ANTRODUODENAL/COLONIC MOTILITY: DOES MANOMETRY CHANGE MANAGEMENT?
Anil Darbari MD, MBA, Children’s National Medical Center
Learning objectives:
1. Review the setup, performance and diagnostic utility of antroduodenal and colonic manometry studies
2. Identify the child with refractory symptoms who may be a candidate for manometry studies
3. Understand the therapeutic options based on the antroduodenal and colonic manometry studies

QUANTIFICATION OF HUMAN COLON ENS USING NOVEL OPTICAL CLEARING METHODS AND 3-DIMENTIONAL IMAGING. Kahleb Graham1, Silvia Huerta Lopez1, Archana Shenoy2, Rajarshi Sengupta3, Michael Feldman4, Emma Furth4, Federico Valdivieso4, Amanda Lemke1, Benjamin Wilkins5, Pierre Russo5, Edward Doolin6, Robert Heuckeroth1,7. 1Gastroenterology , Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; 2Pathology and Laboratory Medicine, University of Florida , Gainesville, FL, USA; 3American Association for Cancer Research, Philadelphia, PA, USA; 4Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; 5Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; 6Pediatric and Thoracic Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; 7Pediatrics , Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

NEUROMODULATION OF THE GI TRACT IN CHILDREN: WHAT’S THE BUZZ?
Peter Lu MD, Nationwide Children’s Hospital
Learning objectives:
1. Review applications of neuromodulation for treatment of gastrointestinal disorders in children
2. Identify the child with refractory nausea and vomiting who may be a candidate for gastric electrical stimulation
3. Understand the role of sacral nerve stimulation in the treatment of the child with severe constipation and fecal incontinence

RET SIGNALING IN THE INTESTINAL EPITHELIUM REGULATES GASTROINTESTINAL MOTILITY.
Laurence Feinstein1, Svetlana Sabel1, Esther Mezhibovsky2, Daniella Rastelli1, Lynley Matthews1, John Russell3, Sanjay Kumar3, Michael Gershon4, Meenakshi Rao1. 1Pediatric Gastroenterology, Columbia University, New York, NY, USA; 2Institute of Human Nutrition, Columbia University, New York, NY, USA; 3GlaxoSmithKline Pharmaceuticals, King of Prussia, PA, USA; 4Department of Pathology and Cell Biology, Columbia University, New York, NY, USA.