10:30am – 12:00pm Concurrent Session I
COLONOSCOPY SKILLS WORKSHOP
Organizers: Douglas Fishman, MD, FASGE, Texas Children's Hospital and Catharine Walsh, MD, MEd, PhD, FRCPC, The Hospital for Sick Children
NEUROGASTROENTEROLOGY
Link to Slides
Moderators: Kara Gross Margolis, MD, Columbia University Medical Center and Jaime Belkind-Gerson, MD, MSc, Children's Hospital Colorado
10:30am
Basic mechanisms for neuro-regeneration and repair
Robert Heuckeroth, MD, PhD, Children's Hospital of Philadelphia
Objectives:
- Understand the structure and many functions of the human enteric nervous system.
- Understand how birth defects and various types of injuries impair enteric nervous system function, causing human disease.
- Understand the newest research suggesting that small molecules and stem cells might allow us to rebuild or replace the enteric nervous system when it is damaged or missing. These basic science discoveries suggest we may be entering a new era in care for people with bowel motility disorders.
10:55am
Are we over- or underdiagnosing pediatric gastroparesis?
Katja Kovacic, MD, Children's Hospital of Wisconsin
Objectives:
- Understand the complexity of gastric physiology and how it relates to upper GI symptoms
- Understand the limitations of current diagnostic modalities
- Appreciate implications for clinical practice and the need for better measures
11:20am
217 IMPAIRED VAGAL EFFICIENCY PREDICTS PAIN REDUCTION WITH PERCUTANEOUS ELECTRICAL NERVE FIELD STIMULATION (PENFS)
THERAPY FOR FUNCTIONAL ABDOMINAL PAIN DISORDERS. Katja Kovacic1, Jacek Kolacz2, Stephen Porges2. 1Department of Pediatrics, Medical
College of Wisconsin, Milwaukee, WI, USA; 2Kinsey Institute, Indiana University, Bloomington, IN, USA.
11:32am
Novel treatments for functional abdominal pain: What’s in the pipeline?
Miguel Saps, MD, University of Miami School of Medicine
Objectives:
- To provide a summary of the current care of children with functional abdominal pain
- Describe pitfalls of current standard of care
- To provide an overview of novel treatments
- Discuss potential alternative approaches to care, opportunities for research and future directions
**INTESTINAL FAILURE: THROUGH THE LENS OF THE LONG TERM SURVIVORS
Link to Slides
Moderators: Debora Duro, MD, MS, Salah Foundation Children's Hospital and Valeria Cohran, MD, Ann & Robert H Lurie Children's Hospital
10:30am
Potential role of new fat emulsions
John Kerner, MD, Stanford University
Objectives:
- Discuss the role of phytosterols in the etiology of intestinal failure associated liver disease
- Review the differences between fat emulsions available in the U.S.
- Describe specific indications for the two new fat emulsions
10:55am
Getting in line: Towards a clinical practice guideline for central venous catheter salvage in home parenteral nutrition patients
Bram Raphael, MD, Boston Children's Hospital
Objectives:
- Preserving venous access can be critical to patient long-term survival
- Factors impacting rates of success in central venous catheter salvage
- Developing a central venous catheter salvage management algorithm, including antimicrobial locks
- Future quality improvement opportunities
11:20am
218 MICROBIAL METABOLITES AS MARKERS OF INTESTINAL DYSBIOSIS IN PEDIATRIC SHORT BOWEL SYNDROME.
Arthur Kastl1, Lindsey Albenberg1, Christina Bales1, Michael Bennett1, Elliot Friedman2, William Mitchell1, Ceylan Tanes1, Natalie Terry1,
Gary Wu2. 1Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; 2Medicine, University of Pennsylvania, Philadelphia, PA, USA.
11:32am
Trophic growth factors: A practical view
Beth Carter, MD, Children's Hospital of Los Angeles
Objectives:
- Review the timeline and design/outcomes of the trials for a new intestinotrophic agent recently FDA-approved for pediatric patients with SBS who are dependent on TPN
- Summarize the medical monitoring guidelines for pediatric patients prescribed a new intestinotrophic agent for pediatric SBS patients who are TPN-dependent
- Discuss the benefits of a multidisciplinary Intestinal Rehabilitation Center in providing multidisciplinary care for SBS and the importance of working together as a medical community to improve access and safe prescribing of a new intestinotrophic agent for ALL potential candidate patients
BASIC SCIENCE OF THE PANCREAS
Link to Slides
Moderators: Alvin Jay Freeman, MD, Emory University Hospital and Tanja Gonska, MD, The Hospital for Sick Children
10:30am
Patient derived Pancreas-on-a-chip to model Cystic Fibrosis related Diabetes
AP Naren, PhD, Cincinnati Children's Hospital Medical Center
Objectives:
- Learn why Cystic Fibrosis (CF) Patients are at a very high risk to develop Cystic Fibrosis Related Diabetes (CFRD) as they get older
- Understand how Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) which is highly expressed in pancreatic ductal epithelial cells, which is in close proximity to pancreatic islets may play a role in insulin secretion
- Understand how Patient derived Pancreatic ductal Organoid technology that we developed to generate a pancreas-on-a-chip, a microfluidic devise with pancreatic ductal epithelial cells on the top chamber and islets on the bottom chamber can help elucidate the relationship between CF and diabetes
10:55am 219 EXPLOITING GLOBAL METABOLOMIC AND LIPIDOMIC PLASMA PROFILING TO IDENTIFY BIOMARKERS THAT WILL PREDICT THE
RISK OF DEVELOPING THE COMPLICATION OF PANCREATITIS WITH THE ANTI-LEUKEMIC DRUG ASPARAGINASE. Li Wen2, Yue Wei3,
Chaitanya Srinivasan4, Paul Fogle5, Sameer Agnihotri6, Ying Ding3, Sohail Husain1. 1Pediatrics, Stanford University, Palo Alto, CA, USA;
2Gastroenterology, Shanghai General Hospital and Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai Municipality, China;
3Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA; 4Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA; 5Metabolon,
Durham, NC, USA; 6Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.
11:07am
A mechanistic approach to pancreatic diseases in children
Aliye Uc, MD, University of Iowa Hospitals & Clinics
Objectives:
- Review most common causes of pancreatic damage in childhood
- Describe mechanisms of most common pancreatic diseases in children
- Understand current management of pediatric pancreatic diseases
11:32am
220 THE DRUG COMPLICATION OF PANCREATIC INJURY WITH ASPARAGINASE IS RELATED TO PANCREATIC LEVELS OF
THE ENDOGENOUS COUNTERACTING ENZYME ASPARAGINE SYNTHETASE AND INTRA-PANCREATIC NUTRIENT STRESS.
Amitava Mukherjee1, Nayyar Ahmed2, Abraheem Ahmad1, Tanveer Javed1, Li Wen3, Sohail Husain4. 1Pediatrics, University of
Pittsburgh, Pittsburgh, PA, USA; 2Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA; 3Gastroenterology, Shanghai General Hospital
and Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai Municipality, China; 4Pediatrics, Stanford University, Palo Alto, CA, USA.
1Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA; 2Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA; 3Gastroenterology,
Shanghai General Hospital and Shanghai Jiao Tong
SURGERY IN IBD (3 “P’S” IN A POD)
Link to Slides
Moderators: Lori Zimmerman, MD, Boston Children's Hospital and Ashish Patel, MD, UT Southwestern Medical Center
10:30am
Problematic pouch
Jeremy Adler, MD, MSc, University of Michigan
Objectives:
- Learn about the risk for developing pouch problems
- Review strategies for evaluating pouch problems
- Understand options for management of pouch problems
10:55am
Penetrating and stricturing Crohn's disease
Nicholas Carman, FRACP, MBBS, BSc, Children's Hospital of Eastern Ontario
Objectives:
- Learn to identify patients at risk for complicated disease
- Differentiate patients who would benefit from surgery vs optimized medical care
- Review medical/endoscopic therapies for patients with stricturing/penetrating disease
11:20am
221 USE OF SMALL BOWEL ULTRASOUND TO PREDICT RESPONSE TO INFLIXIMAB INDUCTION IN PEDIATRIC
CROHN'S DISEASE. Michael Dolinger1, Jungwhan Choi4, Becky Phan3, Henrietta Rosenberg2, John Rowland3, Marla Dubinsky1.
1Pediatric Gastroenterology, Kravis Children's Hospital at Mount Sinai, New York, NY, USA; 2Pediatric Radiology, Kravis
Children's Hospital at Mount Sinai, New York, NY, USA; 3The Mount Sinai Hospital, New York, NY, USA; 4Department of Radiology,
Boston Children's Hospital, Boston, MA, USA.
11:32am
Pre and post surgical management of IBD: A cut above the rest
Dana Michelle Dykes, MD, Children's Center for Digestive Health Care
Objectives:
- To identify strategies for medical optimization surrounding surgery for IBD
- To recognize potentially preventable complications associated with peri-operative care
- To develop opportunities for a patient-centered approach to surgical care of patients with IBD
LIVER TRANSPLANT
Link to Slides
Moderators: Mercedes Martinez, MD, New York-Presbyterian Hospital and Sanjiv Harpavat, MD, PhD, Texas Children's Hospital
10:30am Care of liver transplant recipients for the gastroenterologist
Elizabeth Rand, MD, Children's Hospital of Philadelphia
Objectives:
- Identify routine follow up needs for liver transplant recipients
- Recognize GI luminal complications of liver transplant
- Differentiate complications requiring return to transplant center
10:55am
222 THE ASSOCIATION BETWEEN NEIGHBORHOOD SOCIOECONOMIC MEASURES AND A NOVEL BIOMARKER OF
NONADHERENCE: RESULTS FROM A MULTI-CENTER COHORT. Sharad Wadhwani1, John Bucuvalas2,3, Cole Brokamp1,4, Ravinder
Anand5, Ashutosh Gupta6, stuart taylor1, Eyal Shemesh2, Andrew Beck1,4. 1Cincinnati Children's Hospital Medical Center,
Cincinnati, OH, USA; 2Icahn School of Medicine at Mount Sinai, New York, NY, USA; 3Kravis Children's Hospital, New York, NY, USA;
4University of Cincinnati College of Medicine, Cincinnati, OH, USA; 5The Emmes Corporation, Rockville, MD, USA; 6The Emmes
Corporation, Bangalore, India.
11:07am
Choosing a liver transplant center: Aspects to consider
Evelyn Hsu, MD, Seattle Children's Hospital
Objectives:
- Understand what center-dependent factors influence morbidity and mortality on the pediatric liver waitlist
- Understand what center-dependent factors influence long-term pediatric outcomes following liver transplantation
11:32am
223 LIVER DISEASE ASSESSMENT AND POST-TRANSPLANT LIVER DISEASE EVOLUTION IN ISOLATED HEART TRANSPLANTATION FOR
FONTAN FAILURE AS DETERMINED BY CLINICAL SCORING, MRI AND LIVER BIOPSY. Dellys Soler-Rodriguez1,2, Chad Mao4,2, William Mahle4,2,
Adina Alazraki6,2, Kiery Braithwaite6,2, Shelley Caltharp5,2, Heather Rytting5,2, Joseph Magliocca3,2, kirk kanter7,2, Rene Romero1,2. 1Division of
Pediatric Gastroenterology, Hepatology and Nutrition, Emory University School of Medicine, Atlanta, GA, USA; 2Children's Healthcare of Atlanta,
Atlanta, GA, USA; 3Division of Transplantation, Emory University School of Medicine, Atlanta, GA, USA; 4Sibley Heart Center, Emory University School
of Medicine, Atlanta, GA, USA; 5Division of Pediatric Pathology, Emory University School of Medicine, Atlanta, GA, USA; 6Division of Pediatric
Radiology, Emory University School of Medicine, Atlanta, GA, USA; 7Division of Cardiothoracic Surgery, Emory University School of Medicine,
Atlanta, GA, USA.