Dr. Wells is a professor of Pediatrics at the Cincinnati Children’s Hospital Medical Center. He is in the Division of Developmental Biology and where he established and now directs the human pluripotent stem cell facility. He is also the Director for Basic Research in the Division of Endocrinology. He received his Ph.D. degree in Genetics from the State University of NY at Stony Brook. He performed his postdoctoral research at Harvard University. He became an Assistant professor at the Cincinnati Children’s Hospital Medical Center in the Division of Developmental Biology in 2002, was promoted to associate professor in 2008 and full professor in 2012 and now holds an endowed chair from the Perinatal institute. He has organized regional and international meetings and has given over 140 invited seminars.
Dr. Wells has spent 20 years as a basic researcher to uncover the processes by which gastrointestinal and endocrine organs form in the developing embryo and how they maintain systemic metabolic homeostasis postnatally. This work in developmental biology has provided the basis for the efforts to generate human cells and tissues from pluripotent stem cells. His lab pioneered approaches to generate gastrointestinal (GI) tissue organoids of the stomach, intestine, and colon that are being used to study endocrine control of metabolism, congenital defects of the digestive tract, and enteric pathogens. Moreover, Dr. Wells and colleagues are using organoids as a basis for tissue engineering efforts to generate functional tissues for transplantation. His lab also uses mice and human pluripotent stem cells to study genetic forms of diabetes in humans.
Keynote Address: Organoids: Current and future promise for changing treatment of gastrointestinal and liver disorders
James Wells PhD, Cincinnati Children's Hospital Medical Center
Year in Review
Melvin Heyman MD, UCSF, Editor, Journal of Pediatric Gastroenterology and Nutrition
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