Wednesday, November 6, 2024
EXCEL Single Topic Symposium: EGID Xcelerating Care, Research and Innovation in an Evolving Landscape
Course Directors:
Rajitha D. Venkatesh, MD,MPH, Nationwide Children's Hospital
James P. Franciosi, MD, MS, University of Louisville School of Medicine
Planning Committee:
Carla M. Davis, MD, Texas Medical Center
James P. Franciosi, MD, MS, University of Louisville School of Medicine
Sandeep K. Gupta, MD, University of Alabama
Chris Liacouras, MD, Children's Hospital of Philadelphia
Margaret Marcon, MD, The Hospital for Sick Children
Vincent A. Mukkada, MD, Cincinnati Children's Hospital Medical Center
Nathalie Nguyen, MD, Children's Hospital Colorado
Erin Syverson, MD, Boston Children's Hospital
Rajitha D. Venkatesh, MD, MPH, Nationwide Children's Hospital
7:00 AM - 7:45 AM Morning Mentorship with NIAID & CEGIR Researchers: Career Planning and Mentorship Small Groups
*Non CME/MOC session- First come, first seated
- Amanda Muir, MD, Children's Hospital of Philadelphia
- Glenn T. Furuta, MD, Children's Hospital Colorado
- Mirna Chehade, MD, MPH, Mount Sinai School of Medicine
- Amaziah Coleman, MD, National Institute of Allergy and Infectious Diseases
- Evan Dellon, MD, MPH, University of North Carolina Schoool of Medicine
- Chris Liacouras, MD, Children's Hospital of Philadelphia
- Vincent A. Mukkada, MD, Cincinnati Children's Hospital Medical Center
8:00 AM - 8:30 AM Introduction and Welcome
8:00 AM Welcome
Rajitha D. Venkatesh, MD, MPH, Nationwide Children's Hospital and
James P. Franciosi, MD, MS, University of Louisville School of Medicine
- Introduction / Special Recognition Awards
- Review EXCEL conference modules
8:20 AM Journey of Eosinophilic Esophagitis (EoE) Patient to Young Investigator: Quality of Life to Organoids
James William Moore, EoE patient, pre-medical student, Universtiy of Florida
8:30 AM - 9:35 AM Module 1: EGIDs: History & Pathogenesis
Moderators: Rajitha D. Venkatesh, MD, MPH, Nationwide Children's Hospital and James P. Franciosi, MD, MS, University of Louisville School of Medicine
8:30 AM
Historical Perspective of EoE and non-EoE EGIDs
Chris Liacouras, MD, Children's Hospital of Philadelphia
Learning objectives:
- Describe the clinical history of EoE and non-EoE EGIDs
- Discuss the intersection of EoE and non-EoE EGIDs
8:45 AM
Keynote: Pathogenesis of EGID
Marc Rothenberg, MD, PhD, Cincinnati Children's Hospital Medical Center
Learning objectives:
- Describe the pathogenesis and mechanisms of EoE and non-EoE EGID
- Discuss future EGID basic science research needs and directions
9:05 AM
Evolving Role of Eosinophils and Environmental Agents
Sandeep K. Gupta, MD, Univesity of Alabama at Birmingham
Learning objectives:
- Learn how the relationship between EGIDs and eosinophils has evolved
- Understand the role of environmental agents in EGIDs
- Discuss future investigations into environmental agents and research directions
9:35 AM - 10:20 AM Module 2: Innovation and Advances in Monitoring
Moderators: Kristina L. Leinwand, DO, Kaiser Permanente and Vishal Avinashi, MD, British Columbia Children's Hospital
9:35 AM Innovation: Unsedated Transnasal Endoscopy (TNE) in Eosinophilic GI Disease
Nathalie Nguyen, MD, Children's Hospital Colorado
Learning objectives:
- Identify the indications, opportunities and limitations of TNE
- Assess the benefits, risks and potential adverse events associated with TNE
- Discuss how to integrate TNE into clinical practice
9:50 AM Advancements in Esophageal Testing to Assess Inflammation and Fibrostenosis in EoE
Joshua B. Wechsler, MD, MSci, Ann & Robert H. Lurie Childrens Hospital of Chicago
Learning objectives:
- Understand the role and limitation of EndoFLIP in assessing fibrostenotic disease
- Understand the utility of Esophageal string test/Cytosponge surveillance
- Discuss the when & how of EoE disease monitoring
10:05 AM Artificial Intelligence in EGID
Girish Hiremath, MD, MPH, Monroe Carrell Jr. Children's Hospital At Vanderbilt
Learning objectives:
- Understand EGID data elements, decision making and opportunity for AI in disease monitoring
- Discuss the existing data on the application of AI in healthcare and EGIDs
- Review the potential limitations, pitfalls and future directions of AI research
10:20 AM - 10:30 AM Break
10:30 AM - 12:30 PM Module 3: Xcelerating EoE Care: Advances in Therapy
Moderators: Amaziah Coleman, MD, National Institute of Allergy and Infectious Diseases and Erin Syverson, MD, Boston Children's Hospital
10:30 AM Esophageal Dilation for Children with EoE
Philip E. Putnam, MD, Cincinnati Children's Medical Center
Learning objectives:
- Understand the indications for esophageal dilation
- Understand the various techniques for esophageal dilation
- Understand the risks of esophageal dilation
10:45 AM Therapies Directed at the Antigen(s): Dietary Elimination
Barry K. Wershil, MD, Ann & Robert H. Lurie Children's Hospital of Chicago
Learning objectives:
- Understand the options and outcomes of dietary elimination therapies
- Understand the nutritional impact of the various types of dietary elimination trials
11:00 AM Corticosteroids and Proton Pump Inhibitor (PPI) Therapies for Children with EoE
Rachel Chevalier, MD, Children's Mercy Hospital
Learning objectives:
- Review mechanisms of action, efficacy and adverse effects of corticosteroids
- Review mechanisms of action, efficacy and adverse effects of PPIs
- Discuss pharmacogenomic variation of corticosteroids and PPI therapies
11:15 AM Incorporating Biologics into Your Pediatric EoE Practice
Mirna Chehade, MD, MPH, Icahn School of Medicine at Mount Sinai
Learning objectives
- Review efficacy and safety of current biologics unique to toddlers and children
- Discuss putting it all together for toddlers, children and adolescents: how to incorporate diet, PPIs, corticosteroids and biologics into your practice
11:30 AM Emerging Therapeutics for EoE: Can They be Applied Across the Lifespan?
Evan Dellon, MD, MPH, UNC School of Medicine
Learning objectives:
- Review efficacy and safety of current biologics in adolescents and adults
- Review emerging novel agents for EoE, mechanisms and future clinical research directions across the lifespan
11:50 AM SPARK! Flash Abstract Oral Presentations
Moderator: Diana Lorena Montoya Melo, MD, University of Alabama At Birmingham and Amanda Muir, MD, Children's Hospital of Philadelphia
11:50 AM SYSTEMIC ANALYSIS OF PATIENT DERVIED ESOSPHAGEAL EPITHELIAL ORGANOID MODEL
REVEALS CELL STATE HETEROGENETITY WITH CONSERVATION OF DIFFERENTIATION HIERARCHY
Alyssa Baccarella, MD, MS, Children's Hospital of Philadelphia
11:53 AM ECONOMIC BENEFITS OF PEDIATRIC TNE IMPLEMENTATION
Michael Joseph, MD
, University of Colorado Anschutz Medical Campus
11:56: AM ETRASIMOD TREATMENT OF ACUTE AND CHRONIC MOUSE MODEL OF EOSINOPHILIC
ESOPHAGITIS
Taylor Crue, MPH
, University of Colorado Anschutz Medical Campus, Children's Hospital Colorado
12:05 PM EoE Panel Discussion: Case Based Discussion, Pro-Con
Moderators: Amaziah Coleman, MD, National Institute of Allergy and Infectious Diseases and
Erin Syverson,MD, Boston Children's Hospital
Panel:
- Mirna Chehade, MD, MPH, Mount Sinai School of Medicine
- Evan Dellon, MD, MPH, UNC School of Medicine
- Philip E. Putnam, MD, Cincinnati Children's Medical Center
12:30 PM - 1:30 PM Lunch
12:30 PM - 1:30 PM Concurrent Lunch Session
The who, why and when of recent advances in EGID monitoring; discussion of pros/cons and guidance from experts
*First come, first seated
- Alexander Koral, MD, Yale School of Medicine
- Calies Menard-Katcher, MD, Children's Hospital Colorado
- Nathalie Nguyen, MD, Children's Hospital Colorado
- Vrinda Bhardwaj, MD, Children's Hospital of Los Angeles/ University of Southern California
- Matthew Ryan, MD, Children's Hospital of Philadelphia
12:30 PM - 1:30 PM Concurrent Lunch Session
Ask the Expert: Case-based discussions with expert led small group
*First come, first seated
Group 1: EoE Therapies
Evan Dellon, MD, MPH, University of North Carolina Schoool of Medicine
Amanda Muir, MD, Children's Hospital of Philadelphia
Mirna Chehade Mirna Chehade, MD, MPH, Mount Sinai School of Medicine
Group 2: Non-EoE EGID
Sandeep K. Gupta, MD, University of Alabama at Birmingham
Vincent A. Mukkada, MD, Cincinnati Children's Hospital Medical Center
Margaret Collins, MD, Cincinnati Children's Hospital Medical Center
Group 3: EGIDs from an Allergist Perspective
Carla M. Davis, MD, Howard University College of Medicine
Marc Rothenberg, MD, PhD, Cincinnati Children's Hospital Medical Center
1:40 PM - 3:00 PM Module 4: Xcelerating non-EoE EGID Care
Moderators: Margaret Marcon, MD, Hospital for Sick Children and Calies Menard-Katcher, MD, Children's Hospital Colorado
1:40 PM
Non-EoE Eosinophilic Gastrointestinal Disorders (EGID): New Names, New Paths
Margaret Collins, MD, Cincinnati Children's Hospital Medical Center
Learning objectives:
- Discuss the reasons for the change in nomenclature and remaining issues
- Review the histopathologic threshold values for diagnosis
- Describe additional pathologic features that support non-EoE EGID diagnosis
2:00 PM
Diagnosis and Monitoring of Non-EoE EGIDs for the General Gastroenterologist
Erin Syverson, MD, Boston Children's Hospital
Learning objectives:
- Describe clinical, endoscopic and laboratory findings
- Review the natural history of non-EoE EGIDs
- Understand current recommendations regarding disease monitoring
2:20 PM
A Marathon, Not a Sprint: First Steps in Identifying Therapy in Non-EoE EGID
Vincent A. Mukkada, MD, Cincinnati Children's Hospital Medical Center
Learning objectives:
- Discuss lessons learned from eosinophilic esophagitis applied to non-EoE EGID
- Review existing evidence for dietary and pharmacologic management of non-EoE EGIDs
- Understand current and future directions of research to identify novel therapeutics
2:45 PM
SPARK! Flash Oral Abstracts
Moderators: Dominique Bailey, MD, Columbia University Irving Medical Center and Aakash Goyal, MD,
UT Southwestern
2:45 PM AURICULAR PERCUTANEOUS ELECTRICAL NERVE FIELD STIMULATION IMPROVES PERSISTENT
ABDOMINAL PAIN AND NAUSEA IN PATIENTS WITH EOSINOPHILIC GASTROINTESTINAL
DISORDERS
Neha Santucci, MD
, Cincinnati Children's Hospital Medical Center, University of Cincinnati
College of Medicine
2:48 PM USING AI TO ENHANCE ENDOSCOPIC ASSESSMENT OF PEDIATRIC EOSINOPHILIC ESOPHAGITIS
Girish Hiremath, MD, MPH
, Vanderbilt University Medical Center
2:51 PM ‘I SEE’ INCREASED COMPLICATIONS IN EOSINOPHILIC ESOPHAGITIS PATIENTS NOT COMPLIANT
WITH FOLLOW UP RECOMMENDATIONS
Evan Greenhall, DO
, Phoenix Children's Hospital
3:00 PM - 3:15 PM Break
3:15 PM - 4:30 PM Module 5: Xcelerating Patient-Centered Care for EGIDs
Moderators: Patrice Kruszewski, DO, Nemours Children's Hospital – Delaware and Nonyelum Ebigbo, MD, University of Texas Southwestern Medical Center
3:15 PM
Health Disparities in EGID and How to Address Treatment Outcomes and Quality of Life
Carla M. Davis, MD, Howard University College of Medicine
Learning objectives:
- Describe differences in prevalence and health outcomes in EGIDs
- Understand barriers to diagnosis and treatment in EGIDs
- Implement best practices to reduce barriers to diagnosis and treatment in vulnerable populations
3:30 PM Patient Reported Outcomes: Symptoms, Quality of Life, and Transition of Care
Margaret Marcon, MD, The Hospital for Sick Children
Learning objectives:
- Discuss patients’ and their caregivers’ input as measures of successful treatment
- Understand the current validated tools to assess patient reported outcomes and quality of life
- Understand how to successfully transition to adult care
3:45 PM Patient & Family Perspective: Transition to Adult Care, Quality of Life & Mental Health
Katherine Lamparyk, PsyD, ABPP, Akron Children's Hospital
Learning objectives:
- Understand the role mental health plays in the care of patients with EGID including health-related anxiety and hypervigilance in parents and their children from a psychologist’s perspective
- Understand and implement screening tools for medical PTS, symptom-anxiety, and hypervigilance from a psychologist’s perspective
- Review actionable resources to mitigate adverse mental health impacts
4:05 PM
Panel Discussion
Moderators: Patrice Kruszewski, DO, Nemours Children's Hospital–Delaware and Margaret Marcon, MD, The Hospital for Sick Children
Panel: Carla M. Davis, MD, Howard University College of Medicine and Will Moore, pre-medical student, Universtiy of Flordia
4:30 PM - 5:15 PM Closing Session
4:30 PM SPARK Award winners
Sandeep K Gupta, MD, University of Alabama and Carla M. Davis, MD, Texas Medical Center
4:50 PM EXCEL STS Lessons Learned, Best Practices and Future Directions
Rajitha D. Venkatesh, MD,MPH, Nationwide Children's Hospital and James P. Franciosi, MD, MS,
University of Louisville School of Medicine
5:15 PM - 6:15 PM SPARK! Poster Session and Reception