Wednesday, November 6, 2024
EXCEL Single Topic Symposium: EGID Xcelerating Care, Research and Innovation in an Evolving Landscape


Course Directors:
Rajitha D. Venkatesh, MD,MPH, Nationwide Children's Hospital
James Franciosi, MD, MS, University of Louisville School of Medicine

Planning Committee:
Carla M. Davis, MD, Texas Medical Center
James Franciosi, MD, MS, University of Louisville School of Medicine
Sandeep K Gupta, MD, University of Alabama
Chris Liacouras, MD, Children's Hospital of Philadelphia
Margaret Marcon, MD, Hospital for Sick Children
Vincent A. Mukkada, MD, Cincinnati Children's Hospital Medical Center
Nathalie Nguyen, MD, Children's Hospital Colorado
Erin Syverson, MD, Boston Children's Hospital
Rajitha D. Venkatesh, MD,MPH, Nationwide Children's Hospital

7:00 AM - 7:45 AM Morning Mentorship with NIAID & CEGIR Researchers: Career Planning and Mentorship Small Groups
*Non CME/MOC session- First come, first seated

  • Amanda Muir, MD, Children's Hospital of Philadelphia
  • Glenn T. Furuta, MD, Children's Hospital Colorado
  • Mirna Chehade, MD, MPH, Mount Sinai School of Medicine
  • Amaziah Coleman, MD, National Institute of Allergy and Infectious Diseases
  • Evan Dellon, MD, MPH, University of North Carolina Schoool of Medicine
8:00 AM - 8:15 AM Introduction and Welcome
Moderators: Rajitha D. Venkatesh, MD,MPH, Nationwide Children's Hospital and James Franciosi, MD, MS, University of Louisville School of Medicine
8:05 AM   Journey of Eosinophilic Esophagitis (EoE) Patient to Young Investigator: Quality of Life to Organoids
                 William Moore, EoE patient, pre-medical student, Universtiy of Florida
  
8:15 AM - 9:15 AM Module 1: EGIDs: History & Pathogenesis
Moderators: Rajitha D. Venkatesh, MD,MPH, Nationwide Children's Hospital and James Franciosi, MD, MS, University of Louisville School of Medicine
8:15 AM Historical Perspective of EoE and non-EoE EGIDs
                Chris Liacouras, MD, Children's Hospital of Philadelphia
                Learning objectives:
  • Describe the clinical history of EoE and non-EoE EGIDs
  • Discuss the intersection of EoE and non-EoE EGIDs
  • Review the EXCEL conference modules
8:35 AM Keynote: Pathogenesis of EGID
                Marc Rothenberg, MD, PhD, Cincinnati Children's Hospital Medical Center
                Learning objectives:
  • Describe the pathogenesis and mechanisms of EoE and non-EoE EGID
  • Discuss future EGID basic science research needs and directions
9:05 AM Evolving Role of Eosinophils and Environmental Agents
                Sandeep K. Gupta, MD, Univesity of Alabama at Birmingham
                Learning objectives:
  • Learn how the relationship between EGIDs and eosinophils has evolved
  • Understand the role of environmental agents in EGIDs
  • Discuss future investigations into environmental agents and research directions

9:25 AM - 9:35 AM Break

9:35 AM - 10:20 AM Module 2: Innovation and Advances in Monitoring
Moderators: Kristina L. Leinwand, DO, Kaiser Permanente and Vishal Avinashi, MD, BC Children's Hospital
9:35 AM    Innovation: Unsedated Transnasal Endoscopy in Eosinophilic GI Disease
                  Nathalie Nguyen, MD, Children's Hospital Colorado
                  Learning objectives:
  • Identify the indications, opportunities and limitations of TNE
  • Assess the benefits, risks and potential adverse events associated with TNE
  • Discuss how to integrate TNE into clinical practice
9:50 AM    Advancements in Esophageal Testing to Assess Inflammation and Fibrostenosis in EoE
                  Joshua B. Wechsler, MD, MSci, Ann & Robert H. Lurie Childrens Hospital of Chicago
                  Learning objectives:
  • Understand the role and limitation of FLIP in assessing fibrostenotic disease
  • Understand the utility of Esophageal string test/Cytosponge surveillance
  • Discuss the when & how of EoE disease monitoring
9:50 AM    Artificial Intelligence in EGID
                 Girish Hiremath, MD, MPH, Monroe Carrell Jr. Children's Hospital At Vanderbilt
                 Learning objectives:
  • Understand EGID data elements, decision making and opportunity for AI in disease monitoring
  • Discuss the existing data on the application of AI in healthcare and EGIDs
  • Review the potential limitations, pitfalls and future directions of AI research
10:20 AM - 10:30 AM Break

10:30 AM - 12:30 PM Module 3: Xcelerating EoE Care: Advances in Therapy
Moderators: Amaziah Coleman, MD, National Institute of Allergy and Infectious Diseases and Erin Syverson, MD, Boston Children's Hospital
10:30 AM     Esophageal Dilation for Children with EoE
                    Philip E. Putnam, MD, Cincinnati Children's Medical Center
                    Learning objectives:
  • Understand the indications for esophageal dilation
  • Understand the various techniques for esophageal dilation
  • Understand the risks of esophageal dilation
10:45 AM    Therapies Directed at the Antigen(s): Dietary Elimination and Immunotherapy
                    Barry K. Wershil, MD, Ann & Robert H. Lurie Children's Hospital of Chicago
                    Learning objectives:
  • Understand the options and outcomes of dietary elimination therapies
  • Understand the nutritional impact of the various types of dietary elimination trials
  • Define immunotherapy and its current utility in treating EOE
11:00 AM    Corticosteroids and Proton Pump Inhibitor (PPI) Therapies for Children with EoE
                    Rachel Chevalier, MD, Children's Mercy Hospital
                    Learning Objectives:
  • Review mechanisms of action, efficacy and adverse effects of corticosteroids
  • Review mechanisms of action, efficacy and adverse effects of PPIs
  • Discuss pharmacogenomic variation of corticosteroids and PPI therapies
11:15 AM     Incorportating Biologics into Your Pediatric EoE Practice
                     Mirna Chehade, MD, MPH, Icahn School of Medicine at Mount Sinai
                     Learning objectives
  • Review efficacy and safety of current biologics unique to toddlers and children
  • Discuss putting it all together for toddlers, children and adolescents: how to incorporate diet, PPIs, corticosteroids and biologics into your practice
11:30 AM     Emerging Therapeutics for EoE:  Can They be Applied Across the Lifespan?
                    Evan Dellon, MD, MPH, UNC Schoool of Medicine
                    Learning objectives:
  • Review efficacy and safety of current biologics in adolescents and adults
  • Review emerging novel agents for EoE, mechanisms and future clinical research directions across the lifespan
11:50 AM     SPARK! Flash EoE Abstract Oral Presentations
                    Moderator: Diana Lorena Montoya Melo, MD, University of Alabama At Birmingham
                    11:50 AM Abstract 
                    11:53 AM Abstract
                    11:56: AM Abstract
12:05 PM    EoE Panel Discussion: Case Based Discussion, Pro-Con 
                   Moderators: Amaziah Coleman, MD, National Institute of Allergy and Infectious Diseases and
                   Erin Syverson,MD, Boston Children's Hospital
                   Panel:
  • Mirna Chehade, MD, MPH, Mount Sinai School of Medicine
  • Evan Dellon, MD, MPH, UNC Schoool of Medicine
  • Philip E. Putnam, MD, Cincinnati Children's Medical Center   
12:30 PM - 1:30 PM Lunch 
 
12:30 PM - 1:30 PM Concurrent Lunch Session
The who, why and when of recent advances in EGID monitoring; discussion of pros/cons and guidance from experts
*First come, first seated
  • Alexander Koral, MD, Yale School of Medicine
  • Calies Menard-Katcher, MD, Children's Hospital Colorado
  • Nathalie Nguyen, MD, Children's Hospital Colorado
  • Vrinda Bhardwaj, MD, Childrens Hospital of Los Angeles/ University of Southern California
  • Matthew Ryan, MD, Children's Hospital of Philadelphia

 
12:30 PM - 1:30 PM Concurrent Lunch Session 
Ask the Expert: Case-based discussions with expert led small group
*First come, first seated
    Group 1: EoE Therapies
                   Evan Dellon, MD, MPH, University of North Carolina Schoool of Medicine
                   Amanda Muir, MD, Children's Hospital of Philadelphia
                   Mirna Chehade Mirna Chehade, MD, MPH, Mount Sinai School of Medicine
   Group 2: Non-EoE EGID
                 Sandeep K. Gupta, MD, University of Alabama at Birmingham
                 Vincent A. Mukkada, MD, Cincinnati Children's Hospital Medical Center
                 Margaret Collins, Cincinnati Children's Hospital Medical Center
   Group 3: EGIDs from an Allergist Perspective 
                  Carla M. Davis, MD, Howard University College of Medicine
                  Marc Rothenberg, MD, PhD, Cincinnati Children's Hospital Medical Center

1:30 PM - 1:40 PM Break

1:40 PM - 3:00 PM Module 4: Xcelerating non-EoE EGID Care
Moderators: Margaret Marcon, MD, Hospital for Sick Children and Calies Menard-Katcher, MD, Children's Hospital Colorado
1:40 PM   Non-EoE Eosinophilic Gastrointestinal Disorders (EGID): New Names, New Paths
                  Margaret Collins, MD, Cincinnati Children's Hospital Medical Center
                  Learning objectives:
  • Discuss the reasons for the change in nomenclature and remaining issues
  • Review the histopathologic threshold values for diagnosis
  • Describe additional pathologic features that support non-EoE EGID diagnosis
2:00 PM   Diagnosis and Monitoring of Non-EoE EGIDs for the General Gastroenterologist
                  Erin Syverson, MD, Boston Children's Hospital
                  Learning objectives:
  • Describe clinical, endoscopic and laboratory findings
  • Review the natural history of non-EoE EGIDs
  • Understand current recommendations regarding disease monitoring
2:20 PM   A Marathon, Not a Sprint: First Steps in Identifying Therapy in Non-EoE EGID
                  Vincent A. Mukkada, MD, Cincinnati Children's Hospital Medical Center
                  Learning objectives:
  • Discuss lessons learned from eosinophilic esophagitis applied to non-EoE EGID
  • Review existing evidence for dietary and pharmacologic management of non-EoE EGIDs
  • Understand current and future directions of research to identify novel therapeutics
2:45 PM   SPARK! Flash Non-EOE EGID Abstracts
                  Moderators: Dominique Bailey, MD, Columbia University Irving Medical Center and Aakash Goyal, MD,
                  UT Southwestern
                   2:45 PM Abstract
                   2:48 PM Abstract
                   2:51 PM Abstract

3:00 PM - 3:15 PM Break

3:15 PM - 4:30 PM Module 5: Xcelerating Patient-Centered Care for EGIDs
Moderators:  Patrice Kruszewski, DO, Nemours Children's Hospital – Delaware and Nonyelum Ebigbo, MD, UT Southwestern Medical Center, Children's Health
3:15 PM   Health Disparities in EGID and How to Address Treatment Outcomes and Quality of Life
                  Carla M. Davis, MD, Texas Medical Center
                  Learning objectives:
  • Describe differences in prevalence and health outcomes in EGIDs
  • Understand barriers to diagnosis and treatment in EGIDs
  • Implement best practices to reduce barriers to diagnosis and treatment in vulnerable populations
3:30 PM     Patient Reported Outcomes: Symptoms, Quality of Life, and Transition of Care
                  Margaret Marcon, MD, Hospital for Sick Children
                  Learning objectives:
  • Discuss patients’ and their caregivers’ input as measures of successful treatment
  • Understand the current validated tools to assess patient reported outcomes and quality of life
  • Understand how to successfully transition to adult care
 3:45 PM   Patient & Family Perspective: Transition to Adult Care, Quality of Life & Mental Health
                  Tiffany Taft, PsyD, Oak Park Behavioral Medicine
                  Learning objectives:
  • Understand the role mental health plays in the care of patients with EGID including health-related anxiety and hypervigilance in parents and their children from a psychologist’s perspective
  • Understand and implement screening tools for medical PTS, symptom-anxiety, and hypervigilance from a psychologist’s perspective
  • Review actionable resources to mitigate adverse mental health impacts
4:05 PM   Panel Discussion
Moderators: Patrice Kruszewski, DO, Nemours Children's Hospital–Delaware and Margaret Marcon, MD, Hospital for Sick Children 

Panel: Carla M. Davis, MD, Howard University College of Medicine, Tiffany Taft, PsyD, Oak Park Behavioral Medicine, Will Moore, pre-medical student, Universtiy of Flordia

4:30 PM - 4:40 PM Break

4:40 PM - 5:15 PM Closing Session

4:40 PM   SPARK Award winners
                  Sandeep K Gupta, MD, University of Alabama and Carla M. Davis, MD, Texas Medical Center
4:50 PM    EXCEL STS Lessons Learned, Best Practices and Future Directions
                 Rajitha D. Venkatesh, MD,MPH, Nationwide Children's Hospital and James Franciosi, MD, MS,
                 University of Louisville School of Medicine

5:15 PM - 6:15 PM SPARK! Poster Session and Reception