Concurrent Session I - BASIC SCIENCE OF THE PANCREAS
Moderators:  Alvin Jay Freeman, MD, Emory University Hospital and Tanja Gonska, MD, The Hospital for Sick Children

Patient derived Pancreas-on-a-chip to model Cystic Fibrosis related Diabetes
AP Naren, PhD, Cincinnati Children's Hospital Medical Center
Objectives:
  • Learn why Cystic Fibrosis (CF) Patients are at a very high risk to develop Cystic Fibrosis Related Diabetes (CFRD) as they get older
  • Understand how Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) which is highly expressed in pancreatic ductal epithelial cells, which is in close proximity to pancreatic islets may play a role in insulin secretion
  • Understand how Patient derived Pancreatic ductal Organoid technology that we developed to generate a pancreas-on-a-chip, a microfluidic devise with pancreatic ductal epithelial cells on the top chamber and islets on the bottom chamber can help elucidate the relationship  between CF and diabetes
AP Naren
(Adobe PDF File)
219  EXPLOITING GLOBAL METABOLOMIC AND LIPIDOMIC PLASMA PROFILING TO IDENTIFY BIOMARKERS THAT WILL PREDICT THE RISK OF DEVELOPING THE COMPLICATION OF PANCREATITIS WITH THE ANTI-LEUKEMIC DRUG ASPARAGINASE. Li Wen2, Yue Wei3, Chaitanya Srinivasan4, Paul Fogle5, Sameer Agnihotri6, Ying Ding3, Sohail Husain1. 1Pediatrics, Stanford University, Palo Alto, CA, USA; 2Gastroenterology, Shanghai General Hospital and Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai Municipality, China; 3Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA; 4Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA; 5Metabolon, Durham, NC, USA; 6Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.
Yue Wei
(Adobe PDF File)
A mechanistic approach to pancreatic diseases in children
Aliye Uc, MD, University of Iowa Hospitals & Clinics
Objectives:
  • Review most common causes of pancreatic damage in childhood
  • Describe mechanisms of most common pancreatic diseases in children
  • Understand current management of pediatric pancreatic diseases
Aliye Uc
(Adobe PDF File)
220  THE DRUG COMPLICATION OF PANCREATIC INJURY WITH ASPARAGINASE IS RELATED TO PANCREATIC LEVELS OF THE ENDOGENOUS COUNTERACTING ENZYME ASPARAGINE SYNTHETASE AND INTRA-PANCREATIC NUTRIENT STRESS. Amitava Mukherjee1, Nayyar Ahmed2, Abraheem Ahmad1, Tanveer Javed1, Li Wen3, Sohail Husain4. 1Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA; 2Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA; 3Gastroenterology, Shanghai General Hospital and Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai Municipality, China; 4Pediatrics, Stanford University, Palo Alto, CA, USA.  1Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA; 2Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA; 3Gastroenterology, Shanghai General Hospital and Shanghai Jiao Tong
Sohail Husain
(Adobe PDF File)