CONCURRENT SESSION V  - INFLAMMATORY BOWEL DISEASE: GREAT DEBATES IN IBD

THIOPURINES: TO 6MP OR NOT 6MP, THAT IS THE QUESTION….
Pro - Maria Oliva-Hemker MD, Johns Hopkins University School of Medicine Con - Robert Baldassano MD, Children’s Hospital of Philadelphia
Learning objectives:
1. To understand the potential risk of 6MP
2. To determine the efficacy of 6MP as a monotherapy or as a combination therapy
PHARMACODYNAMIC BIOMARKERS OF RESPONSE TO GLUCOCORTICOIDS AND INFLIXIMAB;VALIDATION AND CORRELATION WITH CLINICAL OUTCOMES IN PEDIATRIC INFLAMMATORY
BOWEL DISEASE. Lina Diaz-Calderon1, Haeri Seol3, Heather Gordish-Dressman2, John Van den Anker2, Yetrib Hathout4, Eric Hoffman4, Laurie Conklin1,2,3. 1Gastroenterology, Hepatology, and Nutrition, Children's National Medical Center, Washington, MD, USA; 2Translational Sciences, Children's National Medical Center, Washington, MD, USA; 3Genetic Medicine Research, Children's National Medical Center, Washington, MD, USA; 4Pharmaceutical Sciences, Binghamton University-SUNY, Binghamton, NY, USA.
PROACTIVE VS. REACTIVE DRUG MONITORING OF BIOLOGIC THERAPIES
Proactive – Andrew Grossman MD, Children’s Hospital of Philadelphia Reactive – Jennifer Strople MD, Ann and Robert Lurie Children’s Hospital Learning objectives:
1. Recognize the clinical utility of implementing therapeutic drug monitoring to optimize the use of biological therapies in the treatment of pediatric inflammatory bowel disease
2. Understand the rationale for a proactive vs. a reactive approach to therapeutic drug monitoring
Andrew Grossman MD - Slides
(Adobe PDF File)
Jennifer Strople MD - Slides
(Adobe PDF File)
ITK HAPLOINSUFFICIENCY AS A CAUSAL DEFECT IN VEO?IBD. Judith Kelsen1, Noor Dawany2, Marcella
Devoto3, Thomas Burn4, Kelly Maurer5, Edward Behrens4, Kathleen Sullivan5. 1Gastroenterology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; 2Department of Biomedical Health, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; 3Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; 4Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; 5Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Judith Kelsen MD - Slides
(Adobe PDF File)