Concurrent Session III - WHAT ARE RESEARCHERS DOING FOR CLINICIANS TODAY? A PERSONALIZED MEDICINE DEBATE
Moderator:  Kathleen Loomes, MD, Children's Hospital of Philadelphia and Bruno Chumpatazi, MD, Texas Children's Hospital/ Baylor College of Medicine

Tools to improve characterization of disease and personalize therapy in children with IBD Ted Denson, MD, Cincinnati Children's Hospital Medical Center vs
Judith Kelsen, MD, Children's Hospital of Philadelphia
Objectives:

• To understand the evaluation and identify patients amenable to targeted therapy in VEO-IBD
• To incorporate clinical phenotype and biomarkers to prognosticate disease course and to target therapy in older children with CD and UC

Personalized medicine in the field of Pancreatology: Ready for prime-time or caution ahead?
Véronique Morinville, MD, Montreal Children's Hospital vs
Maisam Abu-El-Haija, MD, Cincinnati Children's Hospital and Medical Center
Objectives:

• Recognize the importance of genetics and genotype- phenotype correlations in pancreatitis
• Understand the role of precision medicine in pancreatic diseases
• Consider current limitations and concerns in utilizing genetics in pancreas patient care

Personalized medicine in inherited cholestasis: Needs, opportunities and limitations
Kathleen Loomes, MD, Children's Hospital of Philadelphia vs
Benjamin Shneider, MD, Texas Children's Hospital       
Objectives:

• Gain an understanding of the types of genetic tests that are available for inherited cholestasis and how the results may be interpreted
• Be able to describe the lack of a genotype-phenotype relationship in Alagille syndrome and understand that genetic modifiers may play a role in disease outcome
• Be able to describe a range of clinically relevant outcomes in ABCB11 disease that might warrant a need for personalized medicine
• Be able to apply an understanding of genotype-phenotype relationships in ABCB11 disease to personalize clinical-decision making for individuals with specific mutations in ABCB11